You will have to run wiring, but it depends on whether you want to run them from the original head unit, upgrade to a new HU, or wether you want to run them from an external amp.
Any thoughts? Also, where are you putting them?
To fit the OEM tweeters you will need new A pillar trim and run the wires into the door to connect with the woofer I believe. Far easier just to add some aftermarket two way speakers which does make a big difference to the sound instead of the quite poor IMO full range OEM front speakers. Couple of threads on this subject in this section. Not the easiest job especially removing the door cards!